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96-Well Filtration Plate From Varian, Inc. Improves Sensitivity and Precision for Trace Bio-Analysis by LC/MS

PALO ALTO, Calif., Sept 01, 2008 /PRNewswire-FirstCall via COMTEX News Network/ -- Varian, Inc.
(NasdaqGS: VARI) announced today its new filtration plate for sample
preparation. Captiva(TM) NDLipids is a simple to use, non-drip 96-well plate
specially designed to remove phospholipids including lysophosphatidylcholines,
from biofluids.

It is intended for use by analytical chemists in the pharmaceutical and
life science industries performing quantitative and qualitative analyses of
drugs in biofluids. In applications such as drug screening and monitoring in
early discovery, pre-clinical and clinical trials, the lipids, proteins and
surfactants in a biofluid sample must be removed before analysis by liquid
chromatography/mass spectroscopy (LC/MS). Incomplete removal leads to ion
suppression (reduced sensitivity) and, over time, degrades the performance of
both the LC column, reducing column life, and the MS ion source, increasing
maintenance.

Using Captiva NDLipids, plasma extracts are virtually free from endogenous
matrix interferences (over 97% of the phosphatidylcholines are removed). Ion
suppression is significantly reduced resulting in enhanced sensitivity and
precision during trace analysis. The removal of lipid compounds results in
better peak shapes and more reproducible retention times so that Standard
Operating Procedure (SOP) parameters are easily validated. A fast, 3-step,
in-well precipitation protocol is applicable to a wide variety of analytes.
This ensures high sample throughputs and avoids the need for extensive methods
development.

"Captiva NDLipids is a double win for our customers," said Martin
O'Donoghue, Senior Vice President, Scientific Instruments, Varian, Inc. "The
efficient removal of matrix interferences offers improved analytical
sensitivity, and the simple clean up method leads to productivity
enhancements."

For more technical information about Varian products, please visit
http://www.varianinc.com/products/

Varian, Inc. is a leading worldwide supplier of scientific instruments and
vacuum technologies for life science and industrial applications. The company
provides complete solutions, including instruments, vacuum products,
laboratory consumable supplies, software, training and support through its
global distribution and support systems. Varian, Inc. employs approximately
4,000 people worldwide and operates manufacturing facilities in North America,
Europe and Asia Pacific. Varian, Inc. had fiscal year 2007 sales of $921
million, and its common stock is traded on the NASDAQ Global Select Market
under the symbol, "VARI." Further information is available on the company's
Web site: http://www.varianinc.com.

     For More Information, Contact:
     Public Relations
     Varian, Inc.
     650.424.3845
     pr@varianinc.com

SOURCE Varian, Inc.


http://www.varianinc.com/

Copyright (C) 2008 PR Newswire. All rights reserved


 



 
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