Patrick Dempsey

Estimated off-set earnings: $9.8 million
Success may have come late for this 42-year-old former child juggler, but it was certainly worth the wait. Of all the Grey’s Anatomy stars, Dempsey has done the most commercial work. He is currently the face of Serengeti Eyewear and Versace Man, and recently signed a deal with Avon to launch his own signature cologne, Patrick Dempsey Unscripted. Estimated initial earnings: $2.35 million. An avid auto racer, Dempsey signed a million-dollar deal with Amgen to sponsor his team. He has also earned approximately $400,000 doing voice-overs for Mazda and State Farm commercials, in 2006 and 2008, respectively. In 2006, Dempsey and on-screen love Ellen Pompeo earned about $500,000 each for a television and print holiday campaign for women’s apparel retailer New York & Co. And although this earned him at most 10 grand, Dempsey was one of many celebrities who did a spot in 2007 introducing Monday Night Football for ESPN.

Not one to shy away from the big screen, Dempsey has starred in three major motion pictures since the show began: Made of Honor in 2008 (for which he earned an estimated $4 million) and Enchanted ($750,000 to $1 million) and Freedom Writers ($500,000) in 2007.